Article
Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome.
European urology - 1 Feb 2014
Allory Yves, Beukers Willemien, Sagrera Ana, Flández Marta, Marqués Miriam, Márquez Mirari, van der Keur Kirstin A, Dyrskjot Lars, Lurkin Irene, Vermeij Marcel, Carrato Alfredo, Lloreta Josep, Lorente José A, Carrillo-de Santa Pau Enrique, Masius Roy G, Kogevinas Manolis, Steyerberg Ewout W, van Tilborg Angela A G, Abas Cheno, Orntoft Torben F, Zuiverloon Tahlita C M, Malats Núria, Zwarthoff Ellen C, Real Francisco X
Abstract excerpt
BACKGROUND: Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression. OBJECTIVES: To investigate TERT mutation frequency, spectrum, association with expression and clinical outcome, and potential for detection of recurrences in urine in patients with urothelial bladder cancer (UBC). DESIGN, SETTING, AND...
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