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Article

Turning Escherichia coli into a Frataxin-Dependent Organism.

PLoS genetics - 1 May 2015

Roche Béatrice, Agrebi Rym, Huguenot Allison, Ollagnier de Choudens Sandrine, Barras Frédéric, Py Béatrice

Abstract excerpt

Fe-S bound proteins are ubiquitous and contribute to most basic cellular processes. A defect in the ISC components catalyzing Fe-S cluster biogenesis leads to drastic phenotypes in both eukaryotes and prokaryotes. In this context, the Frataxin protein (FXN) stands out as an exception. In eukaryotes, a defect in FXN results in severe defects in Fe-S cluster biogenesis, and in humans, this is associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25996492
DOI: 10.1371/journal.pgen.1005134
PMCID: PMC4440780

Genes

FXN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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