Article
The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
Molecular microbiology - 1 Feb 2015
Roche Béatrice, Huguenot Allison, Barras Frédéric, Py Béatrice
Abstract excerpt
In eukaryotes, frataxin deficiency (FXN) causes severe phenotypes including loss of iron-sulfur (Fe-S) cluster protein activity, accumulation of mitochondrial iron and leads to the neurodegenerative disease Friedreich's ataxia. In contrast, in prokaryotes, deficiency in the FXN homolog, CyaY, was reported not to cause any significant phenotype, questioning both its importance and its actual contribution to Fe-S...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.