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Article

Novel features of the ISC machinery revealed by characterization of Escherichia coli mutants that survive without iron-sulfur clusters.

Molecular microbiology - 1 Mar 2016

Tanaka Naoyuki, Kanazawa Miaki, Tonosaki Keitaro, Yokoyama Nao, Kuzuyama Tomohisa, Takahashi Yasuhiro

Abstract excerpt

Biological assembly of iron-sulfur (Fe-S) clusters is mediated by complex systems consisting of multiple proteins. Escherichia coli possesses two distinct systems called the ISC and SUF machineries encoded by iscSUA-hscBA-fdx-iscX and sufABCDSE respectively. Deletion of both pathways results in absence of the biosynthetic apparatus for Fe-S clusters, and consequent lethality, which has hampered detailed genetic...

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PMID: 26560204
DOI: 10.1111/mmi.13271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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