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Article

Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu.

The Journal of biological chemistry - 2 May 2008

Wang Tao, Craig Elizabeth A

Abstract excerpt

Friedreich ataxia is caused by reduced activity of frataxin, a conserved iron-binding protein of the mitochondrial matrix, thought to supply iron for formation of Fe-S clusters on the scaffold protein Isu. Frataxin binds Isu in an iron-dependent manner in vitro. However, the biological relevance of this interaction and whether in vivo the interaction between frataxin and Isu is mediated by adaptor proteins is a...

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Identifiers

PMID: 18319250
DOI: 10.1074/jbc.M800399200
PMCID: PMC2335353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu.PMID 18319250Read ↗

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Structural bases for the interaction of frataxin with the central components of iron-sulphur cluster assembly.Semantic proximity Read ↗

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