Article

A connection between two ancient and essential cellular processes, iron-sulfur protein biogenesis and fatty acid synthesis, in <i>Escherichia coli</i>

2025-06-16

Abstract excerpt

Iron-sulfur [Fe-S] clusters are ubiquitous cofactors of a wide array of structural and functional diverse proteins. Acyl Carrier Protein (ACP) is the universal factor required for fatty acid (FA) synthesis. In this study in E. coli , we demonstrated that [Fe-S] and FA biosynthesis pathways are coordinated processes, driven by a physical interaction between ACP and the ISC [Fe-S] biogenesis machinery. Using bacter...

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Literature Corpus work: a566ce74-db2b-5a6b-a251-c0128ad5c476
DOI: 10.1101/2025.06.16.659903

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