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Article

Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria.

The Biochemical journal - 1 Apr 2014

Yoon Heeyong, Knight Simon A B, Pandey Alok, Pain Jayashree, Zhang Yan, Pain Debkumar, Dancis Andrew

Abstract excerpt

Frataxin is a conserved mitochondrial protein, and deficiency underlies the neurodegenerative disease Friedreich's ataxia. Frataxin interacts with the core machinery for Fe-S cluster assembly in mitochondria. Recently we reported that in frataxin-deleted yeast strains, a spontaneously occurring m...

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Identifiers

PMID: 24433162
DOI: 10.1042/BJ20131273
PMCID: PMC4021491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24433162-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Frataxin-bypassing Isu1: characterization of the bypass activity in cells and mitochondria.PMID 24433162Read ↗

Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism.Semantic proximity Read ↗

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Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins.Semantic proximity Read ↗

Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, Isu.Semantic proximity Read ↗

Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly.Semantic proximity Read ↗

Iron-induced oligomerization of yeast frataxin homologue Yfh1 is dispensable in vivo.Semantic proximity Read ↗

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