Article
Three Huntington's Disease Specific Mutation-Carrying Human Embryonic Stem Cell Lines Have Stable Number of CAG Repeats upon In Vitro Differentiation into Cardiomyocytes.
PloS one - 1 Jan 2015
Jacquet Laureen, Neueder Andreas, Földes Gabor, Karagiannis Panagiotis, Hobbs Carl, Jolinon Nelly, Mioulane Maxime, Sakai Takao, Harding Sian E, Ilic Dusko
Abstract excerpt
Huntington disease (HD; OMIM 143100), a progressive neurodegenerative disorder, is caused by an expanded trinucleotide CAG (polyQ) motif in the HTT gene. Cardiovascular symptoms, often present in early stage HD patients, are, in general, ascribed to dysautonomia. However, cardio-specific expression of polyQ peptides caused pathological response in murine models, suggesting the presence of a nervous...
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