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The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities

1 Jan 2022

Abstract excerpt

Huntington's disease is caused by a pathologically long (>35) CAG repeat located in the first exon of the Huntingtin gene (HTT). While pathologically expanded CAG repeats are the focus of extensive investigations, non-pathogenic CAG tracts in protein-coding genes are less well characterized. Here, we investigated the function and evolution of the physiological CAG tract in the HTT gene. We show that the...

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PMID: 34974533
DOI: 10.1038/s41418-021-00914-9

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