Article

A Patient-Derived Cellular Model for Huntington’s Disease Reveals Phenotypes at Clinically Relevant CAG Lengths

2018-03-29

Abstract excerpt

<h4>ABSTRACT</h4> The huntingtin protein participates in several cellular processes that are disrupted when the polyglutamine tract is expanded beyond a threshold of 37 CAG DNA repeats in Huntington’s disease (HD). Cellular biology approaches to understand these functional disruptions in HD have primarily focused on cell lines with synthetically long CAG length alleles that clinically represent outliers in this d...

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Literature Corpus work: 9213a131-692c-567d-90f5-716c0847a731
DOI: 10.1101/291575

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