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Generation of induced pluripotent stem cells from three individuals with Huntington's disease.

Stem cell research - 1 Dec 2022

Miller Duncan C, Lisowski Pawel, Lickfett Selene, Mlody Barbara, Bünning Miriam, Genehr Carolin, Ulrich Claas, Wanker Erich E, Diecke Sebastian, Priller Josef, Prigione Alessandro

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disorder caused by abnormal glutamine (Q) expansion in the huntingtin protein due to elongated CAG repeats in the gene HTT. We used non-integrative episomal plasmids to generate induced pluripotent stem cells (iPSCs) from three individuals affected by HD: CH1 (58Q), and two twin brothers CH3 (44Q) and CH4 (44Q). The iPSC lines exhibited one healthy HTT allele and...

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PMID: 36434993
DOI: 10.1016/j.scr.2022.102976

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