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Article

Dysfunction of the CNS-Heart Axis in Mouse Models of Huntington's Disease

7 Aug 2014

Abstract excerpt

Cardiac remodelling and contractile dysfunction occur during both acute and chronic disease processes including the accumulation of insoluble aggregates of misfolded amyloid proteins that are typical features of Alzheimer's, Parkinson's and Huntington's disease (HD). While HD has been described mainly as a neurological disease, multiple epidemiological studies have shown that HD patients exhibit a high incidence...

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PMID: 25101683
DOI: 10.1371/journal.pgen.1004550

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