Article
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity.
Neurobiology of disease - 1 Apr 2012
Camnasio Stefano, Delli Carri Alessia, Lombardo Angelo, Grad Iwona, Mariotti Caterina, Castucci Alessia, Rozell Björn, Lo Riso Pietro, Castiglioni Valentina, Zuccato Chiara, Rochon Christelle, Takashima Yasuhiro, Diaferia Giuseppe, Biunno Ida, Gellera Cinzia, Jaconi Marisa, Smith Austin, Hovatta Outi, Naldini Luigi, Di Donato Stefano, Feki Anis, Cattaneo Elena
Abstract excerpt
Neuronal disorders, like Huntington's disease (HD), are difficult to study, due to limited cell accessibility, late onset manifestations, and low availability of material. The establishment of an in vitro model that recapitulates features of the disease may help understanding the cellular and molecular events that trigger disease manifestations. Here, we describe the generation and characterization of a series of...
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