Article
Experimental evolution of an RNA virus in wild birds: evidence for host-dependent impacts on population structure and competitive fitness.
PLoS pathogens - 1 May 2015
Grubaugh Nathan D, Smith Darci R, Brackney Doug E, Bosco-Lauth Angela M, Fauver Joseph R, Campbell Corey L, Felix Todd A, Romo Hannah, Duggal Nisha K, Dietrich Elizabeth A, Eike Tyler, Beane Jennifer E, Bowen Richard A, Black William C, Brault Aaron C, Ebel Gregory D
Abstract excerpt
Within hosts, RNA viruses form populations that are genetically and phenotypically complex. Heterogeneity in RNA virus genomes arises due to error-prone replication and is reduced by stochastic and selective mechanisms that are incompletely understood. Defining how natural selection shapes RNA virus populations is critical because it can inform treatment paradigms and enhance control efforts. We allowed West Nile...
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