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Article

West Nile virus experimental evolution in vivo and the trade-off hypothesis.

PLoS pathogens - 1 Nov 2011

Deardorff Eleanor R, Fitzpatrick Kelly A, Jerzak Greta V S, Shi Pei-Yong, Kramer Laura D, Ebel Gregory D

Abstract excerpt

In nature, arthropod-borne viruses (arboviruses) perpetuate through alternating replication in vertebrate and invertebrate hosts. The trade-off hypothesis proposes that these viruses maintain adequate replicative fitness in two disparate hosts in exchange for superior fitness in one host. Releasing the virus from the constraints of a two-host cycle should thus facilitate adaptation to a single host. This theory...

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Identifiers

PMID: 22102808
DOI: 10.1371/journal.ppat.1002335
PMCID: PMC3213084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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