Article
Endless Forms: Within-Host Variation in the Structure of the West Nile Virus RNA Genome during Serial Passage in Bird Hosts.
mSphere - 26 Jun 2019
Scroggs Stacey L P, Grubaugh Nathan D, Sena Johnny A, Sundararajan Anitha, Schilkey Faye D, Smith Darci R, Ebel Gregory D, Hanley Kathryn A
Abstract excerpt
RNA viruses are infamous for their high rates of mutation, which produce swarms of genetic variants within individual hosts. To date, analyses of intrahost genetic diversity have focused on the primary genome sequence. However, virus phenotypes are shaped not only by primary sequence but also by the secondary structures into which this sequence folds. Such structures enable viral replication, translation, and...
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