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Article

Complement factor H in AMD: Bridging genetic associations and pathobiology.

Progress in retinal and eye research - 1 Jan 2018

Toomey Christopher B, Johnson Lincoln V, Bowes Rickman Catherine

Abstract excerpt

Age-Related Macular Degeneration (AMD) is a complex multifactorial disease characterized in its early stages by lipoprotein accumulations in Bruch's Membrane (BrM), seen on fundoscopic exam as drusen, and in its late forms by neovascularization ("wet") or geographic atrophy of the Retinal Pigmented Epithelial (RPE) cell layer ("dry"). Genetic studies have strongly supported a relationship between the alternative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28928087
DOI: 10.1016/j.preteyeres.2017.09.001
PMCID: PMC5776047

Genes

CFH
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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