Article
Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant.
Neurobiology of aging - 1 Nov 2008
Alonso Isabel, Marques Joana M, Sousa Nuno, Sequeiros Jorge, Olsson I Anna S, Silveira Isabel
Abstract excerpt
The leaner mutation in mice affects the Ca(v)2.1 voltage-gated calcium channel alpha(1A)-subunit gene (Cacna1a), causing a reduction in calcium currents predominantly in Purkinje cells. This reduction in calcium currents causes severe progressive cerebellar ataxia, beginning around postnatal day 10, in homozygous leaner mice (tg(la)/tg(la)), while their heterozygous littermates (tg(la)/+) present no obvious...
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