Article
Robo1/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice.
Scientific reports - 19 May 2015
Li Jiangchao, Ye Yuxiang, Zhang Renli, Zhang Lili, Hu Xiwen, Han Dong, Chen Jiayuan, He Xiaodong, Wang Guang, Yang Xuesong, Wang Lijing
Abstract excerpt
Secreted Slit proteins and their Roundabout (Robo) receptors act as a repulsive cue to prevent axons from migrating to inappropriate locations during the development of the nervous system. Slit/Robo has also been implicated in reproductive system development, but the molecular mechanism of the Slit/Robo pathway in the reproductive system remains poorly understood. Using a transgenic mouse model, we investigated...
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