Article
Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract.
Biology of reproduction - 1 Mar 2016
Ferguson Lydia, Kaftanovskaya Elena M, Manresa Carmen, Barbara Agustin M, Poppiti Robert J, Tan Yingchun, Agoulnik Alexander I
Abstract excerpt
The Notch signaling pathway is critical for the differentiation of many tissues and organs in the embryo. To study the consequences of Notch1 gain-of-function signaling on female reproductive tract development, we used a cre-loxP strategy and Amhr2-cre transgene to generate mice with conditionally activated Notch1 (Rosa(Notch1)). The Amhr2-cre transgene is expressed in the mesenchyme of developing female...
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