Article
Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice.
PloS one - 1 Jan 2015
Sargent Kevin M, Lu Ningxia, Clopton Debra T, Pohlmeier William E, Brauer Vanessa M, Ferrara Napoleone, Silversides David W, Cupp Andrea S
Abstract excerpt
Because VEGFA has been implicated in follicle development, the objective of this study was to determine the effects of granulosa- and germ cell-specific VEGFA loss on ovarian morphogenesis, function, and female fertility. pDmrt1-Cre mice were mated to floxed VEGFA mice to develop granulosa-/germ cell-specific knockouts (pDmrt1-Cre;Vegfa-/-). The time from mating to first parturition was increased when...
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