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Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†

17 Apr 2020

Abstract excerpt

Wt1 gene encodes a nuclear transcription factor which is specifically expressed in ovarian granulosa cells and testicular Sertoli cells. Our previous studies demonstrated that Wt1 is required for the lineage specification of supporting cells and inactivation of Wt1 results in Sertoli cells to Leydig-like cells transformation. To test whether Wt1 is also involved in lineage maintenance of granulosa cells during...

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PMID: 32301970
DOI: 10.1093/biolre/ioaa042

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Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†PMID 32301970Read ↗

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