Article
A novel baseline hepatitis B virus sequencing-based strategy for predicting adefovir antiviral response.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2015
Wang Yu-Wei, Shan Xuefeng, Huang Yao, Deng Haijun, Huang Wen-Xiang, Zhang Da-Zhi, Chen Juan, Tang Ni, Shan You-Lan, Guo Jin-Jun, Huang Ailong
Abstract excerpt
Adefovir dipivoxil (ADV) is used as first-line monotherapy or rescue therapy in chronic hepatitis B (CHB) patients. In this study, we sought to identify nucleotide changes in the reverse transcriptase (RT) of hepatitis B virus (HBV) at baseline and explore their predictive value for ADV antiviral response. Ultra-deep pyrosequencing (UDPS) was utilized to determine HBV genetic variability within the RT region at...
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