Article
Primer ID ultra-deep sequencing reveals dynamics of drug resistance-associated variants in breakthrough hepatitis C viruses: relevance to treatment outcome and resistance screening.
Antiviral therapy - 1 Jan 2016
Barnard Richard, Chopra Abha, James Ian, Blinco John, Watson Mark W, Jabara Cassandra B, Hazuda Daria, Lemon Stanley M, Mallal Simon, Gaudieri Silvana
Abstract excerpt
BACKGROUND: Use of direct-acting antiviral drugs (DAAs) that target HCV may be hampered by the rapid selection of viral strains that harbour drug resistance-associated variants (RAVs). These RAVs are often associated with a fitness cost and tend to occur on low-frequency strains within treatment-naive subjects. To address the clinical relevance of low frequency RAVs in the setting of DAAs, this study utilized a...
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