Article
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Oncotarget - 25 Oct 2016
Zhang Xiaxia, Li Minran, Xi Hongli, Zhang Renwen, Chen Jianhong, Zhang Yu, Xu Xiaoyuan
Abstract excerpt
AIMS: The dynamics of resistance-associated mutations under combination therapy were explored. METHODS: A total of 46 patients were classified into adefovir (n=14) and entecavir (n=32) groups. In the adefovir (ADV) group, six patients receiving combined therapy were DNA-positive after more than 3 years of therapy. Ultra-deep pyrosequencing was used to analyze the dynamics of multi-drugs resistance mutations....
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