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Article

Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing.

Hepatology (Baltimore, Md.) - 1 Sept 2013

Rodriguez Christophe, Chevaliez Stéphane, Bensadoun Paul, Pawlotsky Jean-Michel

Abstract excerpt

UNLABELLED: Hepatitis B virus (HBV) resistance to nucleoside/nucleotide analogs is frequent. Ultra-deep pyrosequencing (UDPS) is a powerful new tool that can detect minor viral variants and characterize complex quasispecies mixtures. We used UDPS to analyze the dynamics of adefovir-resistant HBV variants in patients with chronic HBV infection in whom adefovir resistance occurred during treatment. Amino acid...

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Identifiers

PMID: 23505208
DOI: 10.1002/hep.26383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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