Article
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.
The Journal of infectious diseases - 1 May 2009
Margeridon-Thermet Severine, Shulman Nancy S, Ahmed Aijaz, Shahriar Rajin, Liu Tommy, Wang Chunlin, Holmes Susan P, Babrzadeh Farbod, Gharizadeh Baback, Hanczaruk Bozena, Simen Birgitte B, Egholm Michael, Shafer Robert W
Abstract excerpt
The dynamics of emerging nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI) resistance in hepatitis B virus (HBV) are not well understood because standard dideoxynucleotide direct polymerase chain reaction (PCR) sequencing assays detect drug-resistance mutations only after they have...
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