Article
A classification model for G-to-A hypermutation in hepatitis B virus ultra-deep pyrosequencing reads.
Bioinformatics (Oxford, England) - 1 Dec 2010
Reuman Elizabeth C, Margeridon-Thermet Severine, Caudill Harrison B, Liu Tommy, Borroto-Esoda Katyna, Svarovskaia Evguenia S, Holmes Susan P, Shafer Robert W
Abstract excerpt
MOTIVATION: G → A hypermutation is an innate antiviral defense mechanism, mediated by host enzymes, which leads to the mutational impairment of viruses. Sensitive and specific identification of host-mediated G → A hypermutation is a novel sequence analysis challenge, particularly for viral deep sequencing studies. For example, two of the most common hepatitis B virus (HBV) reverse transcriptase (RT)...
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