Article
Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients.
Antiviral therapy - 1 Jan 2014
Liu Yan, Liu Wenhui, Li Xiaodong, Xu Zhihui, Wang Xiao, Li Changxing, Chen Li, Xin Shaojie, Xu Dongping
Abstract excerpt
BACKGROUND: The study aimed to clarify whether rtN236V mutation of HBV derived from adefovir dipivoxil (ADV)-refractory patients was associated with drug resistance. METHODS: A total of 18,419 patients from Beijing 302 Hospital were investigated. HBV complete reverse transcriptase region of polymerase was screened by direct sequencing and verified by clonal sequencing if necessary. Replication-competent wild-type...
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