Article
Impact of triplicate testing on HIV genotypic tropism prediction in routine clinical practice.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jun 2012
Symons J, Vandekerckhove L, Paredes R, Verhofstede C, Bellido R, Demecheleer E, van Ham P M, van Lelyveld S F L, Stam A J, van Versendaal D, Nijhuis M, Wensing A M J
Abstract excerpt
Guidelines state that the CCR5-inhibitor Maraviroc should be prescribed to patients infected with R5-tropic HIV-1 only. Therefore, viral tropism needs to be assessed phenotypically or genotypically. Preliminary clinical trial data suggest that genotypic analysis in triplicate is associated with improved prediction of virological response by increasing the detection of X4-tropic variants. Our objective was to...
Topics
- Clinical Laboratory Techniques
- Genotype
- HIV Infections
- HIV-1
- Humans
- RNA, Viral
- Sequence Analysis, DNA
- Viral Tropism
- Virology