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Article

Clinical significance of CYP2C9-status guided valproic acid therapy in children.

Epilepsia - 1 Jun 2015

Bűdi Tamás, Tóth Katalin, Nagy Andrea, Szever Zsuzsa, Kiss Ádám, Temesvári Manna, Háfra Edit, Garami Miklós, Tapodi Adrienn, Monostory Katalin

Abstract excerpt

OBJECTIVES: Valproic acid (VPA)-induced adverse effects, which are sometimes serious in children, can be associated with alterations in VPA metabolism. VPA-evoked toxicity is attributed to both the parent compound and its unsaturated metabolites, primarily formed by the cytochrome P450 (CYP)2C9 enzyme. Thus, patients' CYP2C9-status may account for the predisposition to adverse reactions, and testing CYP2C9-status...

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Source

Identifiers

PMID: 25967074
DOI: 10.1111/epi.13011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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