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Article

Influence of genetic variants of CYP2D6, CYP2C9, CYP2C19 and CYP3A4 on antiepileptic drug metabolism in pediatric patients with refractory epilepsy.

Pharmacological reports : PR - 1 Jun 2017

López-García Miguel A, Feria-Romero Iris A, Serrano Héctor, Rayo-Mares Darío, Fagiolino Pietro, Vázquez Marta, Escamilla-Núñez Consuelo, Grijalva Israel, Escalante-Santiago David, Orozco-Suarez Sandra

Abstract excerpt

BACKGROUND: Identified the polymorphisms of CYP2D6, CYP2C9, CYP2C19 and CYP3A4, within a rigorously selected population of pediatric patients with drug-resistant epilepsy. METHOD: The genomic DNA of 23 drug-resistant epilepsy patients and 7 patients with good responses were analyzed. Ten exons in these four genes were genotyped, and the drug concentrations in saliva and plasma were determined. RESULTS: The...

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Identifiers

PMID: 28343093
DOI: 10.1016/j.pharep.2017.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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