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Article

The pharmacogenomics of valproic acid.

Journal of human genetics - 1 Dec 2017

Zhu Miao-Miao, Li Hui-Lan, Shi Li-Hong, Chen Xiao-Ping, Luo Jia, Zhang Zan-Ling

Abstract excerpt

Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. Adverse effects of valproic acid are rare, but hepatotoxicity is severe in particular in those younger than 2 years old and polytherapy. During valproic acid treatment, it is difficult for prescribers to predict its individual response. Recent advances in the field of pharmacogenomics...

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Identifiers

PMID: 28878340
DOI: 10.1038/jhg.2017.91

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