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Influence of CYP2C9 polymorphism on metabolism of valproate and its hepatotoxin metabolite in Iranian patients.

Toxicology mechanisms and methods - 1 Oct 2010

Amini-Shirazi Noushin, Ghahremani Mohammad Hossein, Ahmadkhaniha Reza, Mandegary Ali, Dadgar Armin, Abdollahi Mohammad, Shadnia Shahin, Pakdaman Hossein, Kebriaeezadeh Abbas

Abstract excerpt

Sodium valproate (VPA) has 16 known metabolites in humans. The 2-ene-VPA has anti-convulsant efficacy and 4-ene-VPA is reported to contribute in VPA hepatotoxicity. The formation of 4-ene-VPA is catalyzed by cytochrome P450 2C9 (CYP2C9). CYP2C9 allele mutation is closely related to the attenuation of the enzymatic activity and 4-ene-VPA production. In the present work, VPA, 2-ene-VPA, and 4-ene-VPA in serum of...

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Identifiers

PMID: 20602621
DOI: 10.3109/15376516.2010.497977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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