Article
Factors Influencing Plasma Concentrations of Valproic Acid in Pediatric Patients With Epilepsy and the Clinical Significance of CYP2C9 Genotypes in Personalized Valproic Acid Therapy.
Therapeutic drug monitoring - 1 Aug 2024
Ma Bingsuo, Yang Kun, Li Xinping, Su Ning, Yu Ting, Zou Yan, Xu Xingmeng, Wang Fei, Cheng Jingdong, Yan Zijun, Chen Tong, Zhang Liangming
Abstract excerpt
BACKGROUND: The aim of this study was to investigate the factors affecting plasma valproic acid (VPA) concentration in pediatric patients with epilepsy and the clinical significance of CYP2C9 gene polymorphisms in personalized dosing using therapeutic drug monitoring and pharmacogenetic testing. METHODS: The medical records of children with epilepsy who underwent therapeutic drug monitoring at our institution...
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