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Article

Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.

The Journal of cell biology - 1 Dec 2008

Mortusewicz Oliver, Roth Wera, Li Na, Cardoso M Cristina, Meisterernst Michael, Leonhardt Heinrich

Abstract excerpt

The multifunctional nuclear protein positive cofactor 4 (PC4) is involved in various cellular processes including transcription, replication, and chromatin organization. Recently, PC4 has been identified as a suppressor of oxidative mutagenesis in Escherichia coli and Saccharomyces cerevisiae. To...

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Source

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Identifiers

PMID: 19047459
DOI: 10.1083/jcb.200808097
PMCID: PMC2592824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19047459-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites.PMID 19047459Read ↗

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A CSB-PAF1C axis restores processive transcription elongation after DNA damage repairSemantic proximity Read ↗

Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNASemantic proximity Read ↗

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FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks.Semantic proximity Read ↗

Human Transcriptional Coactivator PC4 Stimulates DNA End Joining and Activates DSB Repair ActivitySemantic proximity Read ↗

Recruitment of DNA repair synthesis machinery to sites of DNA damage/repair in living human cellsSemantic proximity Read ↗

Non-histone human chromatin protein, PC4 is critical for genomic integrity and negatively regulates autophagySemantic proximity Read ↗

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stressSemantic proximity Read ↗

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