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Comprehensive analysis of the T-cell receptor beta chain gene in rhesus monkey by high throughput sequencing

11 May 2015

Abstract excerpt

Profiling immune repertoires by high throughput sequencing enhances our understanding of immune system complexity and immune-related diseases in humans. Previously, cloning and Sanger sequencing identified limited numbers of T cell receptor (TCR) nucleotide sequences in rhesus monkeys, thus their full immune repertoire is unknown. We applied multiplex PCR and Illumina high throughput sequencing to study the TCRβ...

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PMID: 25961410
DOI: 10.1038/srep10092

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