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Article

Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.

Development (Cambridge, England) - 1 Apr 2014

Chakkalakal Joe V, Christensen Josef, Xiang Wanyi, Tierney Mathew T, Boscolo Francesca S, Sacco Alessandra, Brack Andrew S

Abstract excerpt

Across different niches, subsets of highly functional stem cells are maintained in a relatively dormant rather than proliferative state. Our understanding of proliferative dynamics in tissue-specific stem cells during conditions of increased tissue turnover remains limited. Using a TetO-H2B-GFP reporter of proliferative history, we identify skeletal muscle stem cell, or satellite cells, that retain (LRC) or lose...

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Identifiers

PMID: 24715455
DOI: 10.1242/dev.100842
PMCID: PMC3978835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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