Article
Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2015
Biferi Maria Grazia, Nicoletti Carmine, Falcone Germana, Puggioni Eleonora M R, Passaro Nunzia, Mazzola Alessia, Pajalunga Deborah, Zaccagnini Germana, Rizzuto Emanuele, Auricchio Alberto, Zentilin Lorena, De Luca Gabriele, Giacca Mauro, Martelli Fabio, Musio Antonio, Musarò Antonio, Crescenzi Marco
Abstract excerpt
Although in the last decades the molecular underpinnings of the cell cycle have been unraveled, the acquired knowledge has been rarely translated into practical applications. Here, we investigate the feasibility and safety of triggering proliferation in vivo by temporary suppression of the cyclin-dependent kinase inhibitor, p21. Adeno-associated virus (AAV)-mediated, acute knockdown of p21 in intact skeletal...
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