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Article

Aberrant mitochondrial RNA in the role of aging and aging associated diseases.

Medical hypotheses - 1 Aug 2015

Chen Yucai, Parker W Davis, Chen Hongyi, Yang Kunfang

Abstract excerpt

Accumulations of mitochondrial DNA (mtDNA) mutations associated with aging are evident in multiple human tissues. The role of mtDNA mutations can be observed in an aging animal model such as homozygous knock-in PolgA mice, which have a large colonial expansion of mtDNA mutations. They develop reduced lifespan and premature onset of age-related phenotypes, that are also observed in clinical practice like...

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PMID: 25956734
DOI: 10.1016/j.mehy.2015.04.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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