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Article

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia.

PloS one - 1 Jan 2015

Guo Xing, Zhang Run, Liu Juan, Li Min, Song Chunhua, Dovat Sinisa, Li Jianyong, Ge Zheng

Abstract excerpt

Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). Lymphoid enhancer binding factor 1 (LEF1), a key mediator of Wnt signaling, has been linked to leukemic transformation, and LEF1 mutations have been identified in T-ALL. Here we found LEF1 is highly expressed in 25.0% adult ALL patients and LEF1 high...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25942645
DOI: 10.1371/journal.pone.0125429
PMCID: PMC4420493

Genes

MYC
EFS
JAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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