Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia.

International journal of laboratory hematology - 1 Oct 2021

Erbilgin Yucel, Hatirnaz Ng Ozden, Can Ismail, Firtina Sinem, Kucukcankurt Fulya, Karaman Serap, Karakas Zeynep, Celkan Tulin Tiraje, Zengin Emine, Aylan Gelen Sema, Nihal Ozdemir Gul, Yildirmak Yildiz, Dogru Omer, Tansel Turkan, Khodzhaev Khusan, Toluk Ozlem, Ozbek Ugur, Sayitoglu Muge

Abstract excerpt

INTRODUCTION: The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer including leukemia. Here, we investigated LEF1 isoform expression and genomic variations in acute lymphoblastic leukemia (ALL). METHODS: LEF1 isoform expression was evaluated by quantitative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Gene Expression Regulation, Leukemic

Share to Lymphoid Enhancer-Binding Factor 1

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Prognosis

Share to Protein Isoforms

Source

Identifiers

PMID: 33844466
DOI: 10.1111/ijlh.13513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia.PMID 33844466Read ↗

Overexpression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

[Mutation and expression of LEF1 in adult acute lymphocytic leukemia and their clinical significance].Semantic proximity Read ↗

Differences in expression and function of LEF1 isoforms in normal versus leukemic hematopoiesis.Semantic proximity Read ↗

Clinical significance of lymphoid enhancer-binding factor 1 expression in acute myeloid leukemia.Semantic proximity Read ↗

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemiaSemantic proximity Read ↗

Association of TLX1 gene polymorphisms with the risk of acute lymphoblastic leukemia and B lineage acute lymphoblastic leukemia in Han Chinese children.Semantic proximity Read ↗

The Association of Flap Endonuclease 1 Genotypes with the Risk of Childhood Leukemia.Semantic proximity Read ↗

Expression of Certain Leukemia/Lymphoma Related microRNAs and its Correlation with Prognosis in Childhood Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.