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[Mutation and expression of LEF1 in adult acute lymphocytic leukemia and their clinical significance].

Zhongguo shi yan xue ye xue za zhi - 1 Oct 2014

Liu Juan, Guo Xing, Ge Zheng, Zhang Run, Xu Jing-Yan, Li Min, Wu Yu-Jie, Qiao Chun, Qiu Hai-Rong, Zhang Jian-Fu, Li Jian-Yong

Abstract excerpt

Lymphoid enhancer factor 1 (LEF1) is a key transcription factor in Wingless-type (Wnt) pathway. The present study was aimed to explore the genetic mutation and expression of LEF1, and their clinical significance in adult patients with acute lymphocytic leukemia (ALL). Genomic DNA was amplified and sequenced to detect the mutation of LEF1 in 131 newly diagnosed adult patients with ALL. Quantitative PCR (qPCR) was...

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Identifiers

PMID: 25338559
DOI: 10.7534/j.issn.1009-2137.2014.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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