Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.

doi:10.1021/acschemneuro.5b00043

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Pharmacological characterization of the newly synthesized 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) as a potent NCX3 inhibitor that worsens anoxic injury in cortical neurons, organotypic hippocampal cultures, and ischemic brain.

ACS chemical neuroscience - 19 Aug 2015

Secondo Agnese, Pignataro Giuseppe, Ambrosino Paolo, Pannaccione Anna, Molinaro Pasquale, Boscia Francesca, Cantile Maria, Cuomo Ornella, Esposito Alba, Sisalli Maria Josè, Scorziello Antonella, Guida Natascia, Anzilotti Serenella, Fiorino Ferdinando, Severino Beatrice, Santagada Vincenzo, Caliendo Giuseppe, Di Renzo Gianfranco, Annunziato Lucio

Abstract excerpt

The Na(+)/Ca(2+) exchanger (NCX), a 10-transmembrane domain protein mainly involved in the regulation of intracellular Ca(2+) homeostasis, plays a crucial role in cerebral ischemia. In the present paper, we characterized the effect of the newly synthesized compound 5-amino-N-butyl-2-(4-ethoxyphenoxy)-benzamide hydrochloride (BED) on the activity of the three NCX isoforms and on the evolution of cerebral ischemia....

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PMID: 25942323
DOI: 10.1021/acschemneuro.5b00043

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