Role of Ca(v) 2.3 (alpha1E ) Ca2+ channel in ischemic neuronal injury.

doi:10.1097/00001756-200202110-00018

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Role of Ca(v) 2.3 (alpha1E ) Ca2+ channel in ischemic neuronal injury.

Neuroreport - 11 Feb 2002

Toriyama Hideyuki, Wang Ling, Saegusa Hironao, Zong Shuqin, Osanai Makoto, Murakoshi Takayuki, Noda Tetsuo, Ohno Kikuo, Tanabe Tsutomu

Abstract excerpt

We investigated the role of the Ca(v)2.3 (alpha1E) channel in ischemic neuronal injury using Ca(v)2.3 mutant mice. In focal ischemia model with a complete occlusion of the middle cerebral artery in vivo, infarct at 24 h was significantly larger in Ca(v)2.3 mutant mice compared with that in wild-type controls. In vitro Ca2+ imaging studies using hippocampal slices revealed that oxygen-glucose deprivation induced a...

Topics

Animals
Bicuculline
Brain Ischemia
Calcium
Calcium Channels
Calcium Channels, R-Type
Cation Transport Proteins
Cerebral Infarction
GABA Antagonists
Genotype
Hippocampus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Vitro Techniques

Mice

Mice, Mutant Strains

Nervous System

Sodium Channel Blockers

Tetrodotoxin

Source

Open in PubMed

Identifiers

PMID: 11893922
DOI: 10.1097/00001756-200202110-00018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Ca(v) 2.3 (alpha1E ) Ca2+ channel in ischemic neuronal injury.PMID 11893922Read ↗

Hypoxic-ischemic brain injury exacerbates neuronal apoptosis and precipitates spontaneous seizures in glucose transporter isoform 3 heterozygous null mice.Semantic proximity Read ↗

Kir6.2-containing ATP-sensitive potassium channels protect cortical neurons from ischemic/anoxic injury in vitro and in vivo.Semantic proximity Read ↗

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.Semantic proximity Read ↗

Analysis of the protective effects of a neuronal Cav2.1 calcium channel in brain injury.Semantic proximity Read ↗

Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations.Semantic proximity Read ↗

[Effects of lidocaine on brain damage induced by transient global cerebral ischemia in mice of different apolipoprotein E genotypes].Semantic proximity Read ↗

Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages.Semantic proximity Read ↗

Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.Semantic proximity Read ↗

Effects of Amyloid-β Peptides on Voltage-Gated L-Type CaV1.2 and CaV1.3 Ca2+ ChannelsSemantic proximity Read ↗

Levetiracetam-mediated emotional behavior in heterozygous rolling Nagoya Ca(V)2.1 channel mutant mice.Semantic proximity Read ↗

Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.Semantic proximity Read ↗

Protection against hypoxic-ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.