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Article

Effect of overexpression of the brain-specific Na(+)/Ca(2+) exchanger splice variant NCX1.5 on NO cytotoxicity in HEK293 cells.

Journal of pharmacological sciences - 1 Jan 2013

Ota Yuki, Kawanai Takuya, Watanabe Ryo, Nishimura Akira, Ago Yukio, Takuma Kazuhiro, Matsuda Toshio

Abstract excerpt

Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na(+)/Ca(2+) exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the HEK293 cell expression system. Cells were transfected with the plasmid construct pcDNA3.1/V5-His containing full-length rat NCX1.5 cDNA. There was no difference in the...

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Identifiers

PMID: 23538676
DOI: 10.1254/jphs.13012sc

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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