Article
Gene-gene interaction of μ-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect.
Drug metabolism and personalized therapy - 1 Jun 2015
Misailidis Georgios, Ragia Georgia, Ivanova Desislava D, Tavridou Anna, Manolopoulos Vangelis G
Abstract excerpt
BACKGROUND: Components of nicotine reward system can potentially influence smoking behavior. The μ-opioid receptor (OPRM1) binds the endogenous opioid peptide β-endorphin and mediates the reinforcing effects of nicotine, while the GluR5 kainate receptor subunit (encoded by GRIK1 gene), a binding site for known mediators of glutamate neurotransmission, potentially affects the glutaminergic system that is also...
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