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Article

Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence.

Drug metabolism and personalized therapy - 1 Sept 2016

Ragia Georgia, Veresies Ivan, Veresie Louiza, Veresies Kyriakos, Manolopoulos Vangelis G

Abstract excerpt

BACKGROUND: The reinforcing effects of alcohol are mediated through complex interactions between multiple neurochemical systems. Genes of dopaminergic (DRD2, DRD3 and DβH), opioid (OPRM1) and glutaminergic (GRIK1) systems mediate the dependent behavior via different mechanisms; however, they all target the serotonergic and dopaminergic pathways in the ventral tegmental area. METHODS: In the present study, DRD2...

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Alcoholism
Dopamine beta-Hydroxylase
Epistasis, Genetic
Genetic Association Studies
Receptors, Dopamine D2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Dopamine D3

Receptors, Kainic Acid

Receptors, Opioid, mu

Source

Identifiers

PMID: 27447243
DOI: 10.1515/dmpt-2016-0015

Genes

DRD2
DRD3
GRIK1
OPRM1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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