Article
Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.
Alcoholism, clinical and experimental research - 1 May 2009
Kranzler Henry R, Gelernter Joel, Anton Raymond F, Arias Albert J, Herman Aryeh, Zhao Hongyu, Burian Linda, Covault Jonathan
Abstract excerpt
BACKGROUND: Glutamate neurotransmission plays an important role in a variety of alcohol-related phenomena, including alcohol self-administration by both animals and humans. Because the risk for alcohol dependence (AD) is genetically influenced, genes encoding glutamate receptors are candidates to contribute to the risk for AD. We examined the role of variation in the 3' region of GRIK1, the gene that encodes the...
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