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Article

Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens.

Journal of virology - 1 Sept 2015

Fonville Judith M

Abstract excerpt

UNLABELLED: Adaptation is a common theme in both pathogen emergence, for example, in zoonotic cross-species transmission, and pathogen control, where adaptation might limit the effect of the immune response and antiviral treatment. When such evolution requires deleterious intermediate mutations, fitness ridges and valleys arise in the pathogen's fitness landscape. The effect of deleterious intermediate mutations...

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Identifiers

PMID: 26109724
DOI: 10.1128/JVI.00832-15
PMCID: PMC4542389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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